Friday, February 13, 2004

12 noon

Redwood Neuroscience Institute

 

Title:  Neural network interactions in speech perception

 

Lee Miller

D'Esposito Lab

University of California, Berkeley

 

Abstract:

Watching a speaker’s mouth movements improves comprehension, both for normal listeners in noisy environments and especially for the hearing-impaired.  Several brain regions have repeatedly been implicated in crossmodal speech tasks:  left superior temporal sulcus, intraparietal sulcus, V5 complex, and several frontal cortical areas.  There is however little evidence to distinguish these areas functionally -- for instance whether their role is in sensory processing (evaluating spatiotemporal proximity) or specifically in perceptual fusion.  In an event-related fMRI study, eleven human subjects were presented with nonsense vowel-consonant-vowel audiovisual utterances.  The auditory and visual parts of the stimuli occurred either simultaneously or offset in time.  Subjects responded with a button press to indicate whether they experienced audiovisual stimuli as fused or not.  We evaluated the BOLD (blood oxygenation level dependent) sensitivity of crossmodally responsive regions to changes in the subject’s percept regardless of stimulus coincidence, and to changes in stimulus coincidence regardless of the subject’s percept.  Many crossmodal areas, such as superior temporal sulcus, were more consistently involved in perceptual fusion.  Other areas, such as the anterior insula, were more involved with evaluating the spatiotemporal proximity of speech stimuli, regardless of a subject’s percept.  Differential network interactions among these regions demonstrate how low-level sensitivity to the physical properties of stimuli may become manifest in the experience of perceptual fusion.